The word santiguaríais is the conditional form of santiguar in the second person plural. See the full santiguar conjugation.
transitive verb
1. (religious) 
La señora santiguó a sus hijos cuando los dejó en el colegio.The woman made the sign of the cross over her kids when she left them at school.
b. to bless 
El sacerdote santiguó a los niños bautizados.The priest blessed the baptized children.
reflexive verb
2. (religious) 
Un hombre entró a la iglesia, se arrodilló frente al altar y se santiguó.A man went into the church, kneeled before the altar, and crossed himself.
Los feligreses se santiguaron antes de leer el evangelio.The congregation made the sign of the cross before reading the gospel.
transitive verb
1. (general) 
a. to make the sign of the cross over 
pronominal verb
2. (general) 
a. to cross oneself 
transitive verb
1 (bendecir) to make the sign of the cross over; bless
2 (pegar) to slap; hit
3 (Latinoamérica) (sanear) to heal; heal by blessing
pronominal verb
1 (persignarse) to cross o.s.
2 (exagerar) to make a great fuss
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