Unlike in English, where "missus" is usually abbreviated to "Mrs.," "señora" is very often spelled out in Spanish (except in the opening lines of correspondence, as in "Estimada Sra. Guzmán").
When the title of "señora" is being used to refer to someone in the third person, a definite article must precede it: "La señora López me vino a visitar." ("Mrs. López came to visit me.")
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