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Quick answer
"Upon" is a preposition which is often translated as "en", and "depend on" is a transitive verb phrase which is often translated as "depender de". Learn more about the difference between "upon" and "depend on" below.
A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (on)
a. en
He put his hand upon my hip and we danced.Puso su mano en mi cadera y bailamos.
b. sobre
I placed candles upon the mantel.Coloqué velas sobre la repisa.
2. (about)
a. sobre
She informed the audience of her thoughts upon the issue.Ella informó a la audiencia de sus pensamientos sobre el tema.
3. (immediately after)
a. al
Upon realizing what the situation was, he left.Al darse cuenta de la situación, se fue.
b. en cuanto
Upon seeing the body, she began to cry.En cuanto vio el cuerpo, se puso a llorar.
c. tras
Upon the president's arrival, the national anthem was sung.Tras la llegada del presidente, se cantó el himno nacional.
4. (used to indicate large amounts)
a. y
Thousands upon thousands of dead fish appeared on the beach.Aparecieron miles y miles de peces muertos en la playa.
b. tras
He drank beer upon beer until he passed out.Bebió una cerveza tras otra hasta que se desmayó.
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depend on(
A transitive verb phrase is a phrase that combines a verb with a preposition or other particle and requires a direct object (e.g. Take out the trash.).
transitive verb phrase
1. (to be dependent on)
a. depender de
The city depends on the water from the lake.La ciudad depende del agua del lago.
2. (to rely on)
a. contar con
I would never lie to you. You can depend on me.Nunca te mentiría. Puedes contar conmigo.
b. confiar en
Tiffany is unstable. You can't depend on her at all.Tiffany es inestable. No puedes confiar en ella para nada.
3. (to be determined by)
a. depender de
I'll arrive today or tomorrow. It depends on the flight schedule.Llegaré hoy o mañana. Depende del horario de los vuelos.
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