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"The fact that" is a phrase which is often translated as "el hecho de que", and "of" is a preposition which is often translated as "de". Learn more about the difference between "the fact that" and "of" below.
the fact that()
A phrase is a group of words commonly used together (e.g., once upon a time).
1. (general)
a. el hecho de que
The fact that you drove all night to see her is quite impressive.El hecho de que manejaste toda la noche para verla es muy impresionante.
of()
A preposition is a word that indicates the relationship between a noun and another word (e.g., He ran through the door.).