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Quick answer
"Estar a cargo" is an intransitive verb phrase which is often translated as "to be in charge", and "manejar" is a transitive verb which is often translated as "to handle". Learn more about the difference between "estar a cargo" and "manejar" below.
estar a cargo(
ehs
-
tahr
 
ah
 
kahr
-
goh
)
An intransitive verb phrase is a phrase that combines a verb with a preposition or other particle and does not require a direct object (e.g. Everybody please stand up.).
intransitive verb phrase
1. (general)
a. to be in charge
Esto es un caos total. ¿Quién está a cargo?This is total chaos! Who's in charge?
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manejar(
mah
-
neh
-
hahr
)
A transitive verb is a verb that requires a direct object (e.g. I bought a book.).
1. (to deal with)
a. to handle
Un cajero de casino maneja mucho dinero.A casino cashier handles a lot of money.
b. to use
Hay que saber cómo manejar los datos para sacarles máximo provecho.You need to know how to use the data to get the most out of it.
c. to operate
¿Has aprendido a manejar la nueva maquinaria?Have you learned how to operate the new machinery?
2. (to direct)
a. to run
Un conglomerado extranjero ha manejado la empresa desde enero.A foreign conglomerate has run the company since January.
b. to manage
Me contrataron para manejar la bodega.They hired me to manage the warehouse.
3. (to manipulate)
a. to manipulate
El director de la empresa maneja a sus empleados como quiere.The company director manipulates his staff at will.
4. (automobile)
Regionalism used in Latin America: all the countries in South America, Central America, and the Caribbean. Does not include Spain.
(Latin America)
a. to drive
Mi padre me deja manejar su carro los fines de semana.My dad lets me drive his car on weekends.
An intransitive verb is one that does not require a direct object (e.g. The man sneezed.).
5. (automobile)
Regionalism used in Latin America: all the countries in South America, Central America, and the Caribbean. Does not include Spain.
(Latin America)
a. to drive
Voy a aprender a manejar este verano.I'm going to learn to drive this summer.
manejarse
A pronominal verb always uses a reflexive pronoun. (e.g. Te ves cansado.).
6. (to handle oneself)
a. to get by
Se maneja muy bien en chino y ruso.She gets by very well in Chinese and Russian.
b. to manage
Se maneja perfectamente en su nuevo empleo.She's managing perfectly well in her new job.
7. (to act)
a. to behave
Los niños se manejaron muy bien en la excursión.The children behaved really well on the field trip.
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