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Quick answer
"En serio" is an adverb which is often translated as "seriously", and "no" is an adverb which is often translated as "no". Learn more about the difference between "en serio" and "no" below.
en serio(
ehn
 
seh
-
ryoh
)
An adverb is a word that describes a verb, an adjective, or other adverbs (e.g. to run quickly, very tired).
1. (solemnly)
a. seriously
No hay que tomarse la vida tan en serio.We shouldn't take life so seriously.
2. (for real)
a. seriously
Yo te puedo ayudar, en serio.I can help you, seriously.
3. (earnestly)
a. seriously
Se nos echan los exámenes encima y me tengo que poner a estudiar muy en serio.The exams are almost here, and I really have to get down to studying seriously.
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no(
noh
)
An adverb is a word that describes a verb, an adjective, or other adverbs (e.g. to run quickly, very tired).
1. (negation)
a. no
¿Te gustó el concierto? - No, ese estilo de música no me gusta.Did you like the concert? - No, I don't like that style of music.
b. not
No está lloviendo.It's not raining.
c. non-
Una organización no gubernamental es una asociación que actúa con independencia del gobierno.A non-governmental organization is an association that operates independently of government.
2. (in tag questions; asking confirmation)
a.
This refers to an idiomatic word or phrase for which there is no word-for-word translation.
no direct translation
Vamos a la fiesta esta noche ¿no?We're going to the party tonight, aren't we?
Firmaste el contrato ¿no?You signed the contract, didn't you?
3. (in tag questions; to make suggestions)
a.
This refers to an idiomatic word or phrase for which there is no word-for-word translation.
no direct translation
Te acompaño ¿no?I'll come with you, shall I?
Deberíamos llamarlos ¿no?We should call them, shouldn't we?
An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g. Wow!).
4. (negation)
a. no
Quiero que limpies tu cuarto ahora mismo. - ¡No!I want you to clean your room right now. - No!
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