QUICK ANSWER
"Desde que" is a phrase which is often translated as "since", and "desde" is a preposition which is often translated as "from". Learn more about the difference between "desde que" and "desde" below.
desde que(
dehs
-
deh
keh
)A phrase is a group of words commonly used together (e.g., once upon a time).
1. (general)
a. since
No lo he vuelto a ver desde que cambió de trabajo.I haven't seen him since he changed jobs.
b. ever since
Desde que Sarita aprendió a coser, ha hecho toda la ropa de sus hijos.Ever since Sarita learned how to sew, she has made all of her children's clothes.
c. from the moment
No para de llorar desde que se levanta hasta que se acuesta.He doesn't stop crying from the moment he gets up to the moment he goes to bed.
desde(
dehs
-
deh
)A preposition is a word that indicates the relationship between a noun and another word (e.g., He ran through the door.).