QUICK ANSWER
"Although" is a conjunction which is often translated as "aunque", and "in spite of" is a preposition which is often translated as "a pesar de". Learn more about the difference between "although" and "in spite of" below.
although(
al
-
tho
)A conjunction is a word that connects words, phrases, clauses, or sentences (e.g. The cat and the dog slept.).
1. (though)
in spite of(
ihn
spayd
uhv
)A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (despite)
a. a pesar de
We went to the baseball game in spite of the rain.Fuimos al partido de béisbol a pesar de la lluvia.
