a. in spite of
Pese a todo lo que dije de Eva, creo que en el fondo es buena persona.In spite of everything I said about Eva, I think deep down she's a good person.
b. despite of
La inflación se ha disparado, pese a los esfuerzos del banco central por mantenerla a un mínimo.Inflation has shot up, despite of the central bank's efforts to keep it at a minimum.
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