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A masculine noun is used with masculine articles and adjectives (e.g. el hombre guapo, el sol amarillo).
El gene de la anemia falciforme es recesivo, lo que quiere decir que no se manifiesta necesariamente en el fenotipo del individuo que lo tiene.The sickle cell anemia gene is recessive, which means that it doesn't necessarily manifest itself in the phenotype of the individual who has it.
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