had toughened
Past perfectconjugation oftoughen.There are other translations for this conjugation.

toughen

Essentially, the stimulation of the macrophages' CB2 receptors had toughened up their overall resistance to the infection.
Básicamente, la estimulación de los receptores CB2 de los macrófagos había aumentado su resistencia general a la infección.
Morihei over the previous years had toughened his skull by pounding it against a stone slab a 100 times each day. Morihei was in Manchuria for 18 months but apparently never saw action.
Morihei en los últimos años ha templado su cráneo por golpear contra una losa de piedra a 100 veces cada día.Morihei fue en Manchuria durante 18 meses, pero al parecer nunca vio acción.
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