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Quick answer
"In spite of" is a preposition which is often translated as "a pesar de", and "despite that" is a phrase which is often translated as "a pesar de eso". Learn more about the difference between "in spite of" and "despite that" below.
in spite of(
A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (despite)
a. a pesar de
We went to the baseball game in spite of the rain.Fuimos al partido de béisbol a pesar de la lluvia.
b. pese a
In spite of everything I still love her.Pese a todo la sigo queriendo.
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despite that(
A phrase is a group of words commonly used together (e.g once upon a time).
1. (general)
a. a pesar de eso
Our budget has been significantly cut this year, but despite that, we will go ahead with our project.Este año, han reducido nuestro presupuesto de manera significativa, pero a pesar de eso, seguiremos adelante con nuestro projecto.
b. pese a eso
Unemployment is on the rise. Despite that, some positive signals seem to be emerging.El desempleo está en aumento. Pese a eso, parecerían estar surgiendo algunas señales positivas.
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