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"In spite of" is a preposition which is often translated as "a pesar de", and "despite" is a preposition which is also often translated as "a pesar de". Learn more about the difference between "in spite of" and "despite" below.
in spite of(  
ihn
spayd
uhv
)A preposition is a word that indicates the relationship between a noun and another word (e.g., He ran through the door.).
1. (despite)
a. a pesar de 
We went to the baseball game in spite of the rain.Fuimos al partido de béisbol a pesar de la lluvia.
despite(
dih
-
spayt
)A preposition is a word that indicates the relationship between a noun and another word (e.g., He ran through the door.).
a. a pesar de 
She was the one who paid the rent, despite having a much lower income.Era ella quien pagaba el alquiler, a pesar de tener unos ingresos mucho más bajos.
b. pese a 
Obama signed sanctions against Venezuela despite threats from Maduro.Obama firmó sanciones contra Venezuela pese a las amenazas de Maduro.