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Quick answer
"En" is a preposition which is often translated as "in", and "se" is a pronoun which is often translated as "themselves". Learn more about the difference between "en" and "se" below.
A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (indicating place)
a. in
Hay comida ya preparada en el supermercado.There's ready-made food in the supermarket.
b. on
Puedes poner los cubiertos en la mesa. You can put the silverware on the table.
2. (indicating time)
a. on
En 1969, aterrizamos en la luna.In 1969, we landed on the moon.
3. (indicating mode)
a. in
Si un oso te persigue, corre en zigzag.If a bear is chasing you, run in a zig-zag formation.
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A pronoun is a word that stands in for a noun (e.g. she).
1. (reflexive)
a. themselves (plural)
Se compraron un coche nuevo.They bought themselves a new car.
b. itself (singular, neuter)
A mi gato le gusta lamerse.My cat loves licking itself.
c. himself (singular, masculine)
Se está afeitando.He is shaving himself.
d. herself (singular, feminine)
Ya se viste ella sola.She can already dress herself.
2. (reciprocal)
a. each other
Se miraron y sonrieron.They looked at each other and smiled.
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