"En" is a preposition which is often translated as "in", and "no sé" is a phrase which is often translated as "I don't know". Learn more about the difference between "en" and "no sé" below.
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A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (indicating place)
2. (indicating time)
3. (indicating mode)