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"En" is a form of "en", a preposition which is often translated as "in". "No sé" is a phrase which is often translated as "I don't know". Learn more about the difference between "en" and "no sé" below.
en()
A preposition is a word that indicates the relationship between a noun and another word (e.g., He ran through the door.).
no sé()
A phrase is a group of words commonly used together (e.g., once upon a time).
1. (general)