vs
QUICK ANSWER
"En" is a form of "en", a preposition which is often translated as "in". "Ellos" is a form of "ellos", a pronoun which is often translated as "they". Learn more about the difference between "en" and "ellos" below.
en(
ehn
)A preposition is a word that indicates the relationship between a noun and another word (e.g., He ran through the door.).
ellos(
eh
-
yohs
)A pronoun is a word that stands in for a noun (e.g., she).
b. them (after prepositions)
Si confías en ellos, dales las llaves.If you trust them, give them the keys.
c. them (in comparisons)
Mi hermano y yo somos tan altos como ellos.My brother and I are as tall as them.