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Quick answer
"En" is a preposition which is often translated as "in", and "de esta manera" is an adverb which is often translated as "in this way". Learn more about the difference between "en" and "de esta manera" below.
en(
ehn
)
A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (indicating place)
a. in
Hay comida ya preparada en el supermercado.There's ready-made food in the supermarket.
b. on
Puedes poner los cubiertos en la mesa. You can put the silverware on the table.
2. (indicating time)
a. on
En 1969, aterrizamos en la luna.In 1969, we landed on the moon.
3. (indicating mode)
a. in
Si un oso te persigue, corre en zigzag.If a bear is chasing you, run in a zig-zag formation.
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de esta manera(
deh
 
ehs
-
tah
 
mah
-
neh
-
rah
)
An adverb is a word that describes a verb, an adjective, or other adverbs (e.g. to run quickly, very tired).
1. (thus)
a. in this way
No debemos actuar de esta manera.We shouldn't act in this way.
b. this way
¿Cómo puedes tratar a Craig de esta manera?How can you treat Craig this way?
c. like this
Siento seguir molestándote de esta manera, pero necesito tu ayuda.I'm sorry to keep bothering you like this, but I need your help.
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