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Quick answer
"En" is a preposition which is often translated as "in", and "de esa manera" is a phrase which is often translated as "in that way". Learn more about the difference between "en" and "de esa manera" below.
en(
ehn
)
A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (indicating place)
a. in
Hay comida ya preparada en el supermercado.There's ready-made food in the supermarket.
b. on
Puedes poner los cubiertos en la mesa. You can put the silverware on the table.
2. (indicating time)
a. on
En 1969, aterrizamos en la luna.In 1969, we landed on the moon.
3. (indicating mode)
a. in
Si un oso te persigue, corre en zigzag.If a bear is chasing you, run in a zig-zag formation.
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de esa manera(
deh
 
eh
-
sah
 
mah
-
neh
-
rah
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (general)
a. in that way
Quizá pida el traslado a Mérida. De esa manera Claudia y yo podríamos vivir juntos.I might ask for a transfer to Merida. In that way Claudia and I could live together.
b. that way
Nunca antes había hecho la mayonesa de esa manera, pero estaba buenísima.I'd never made mayonnaise that way before, but it was really nice.
c. like that
Siento haberte gritado de esa manera, pero estaba muy nervioso.I'm sorry I shouted at you like that, but I was very nervous.
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