Quick answer
"De qué" is a phrase which is often translated as "what", and "seguro" is an adjective which is often translated as "safe". Learn more about the difference between "de qué" and "seguro" below.
de qué(
deh
 
keh
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (interrogative)
a. what
Necesito saber de qué se trata.I need to know what it's about.
¿De qué estás hablando?What are you talking about?
b. which
Platicaron acerca de qué escuela iban a elegir para su hija.They talked about which school they would choose for their daughter.
c. from which
¿De qué país eres?Which country are you from?
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seguro(
seh
-
goo
-
roh
)
An adjective is a word that describes a noun (e.g. the big dog).
1. (out of danger)
a. safe
El lugar más seguro de la casa durante un tornado es el sótano.The safest place in a house during a tornado is the basement.
2. (confident in an idea)
a. sure
¿Estás seguro que quieres nadar con tiburones?Are you sure you want to swim with sharks?
3. (stable)
a. secure
No te encarames en esa silla, ¡no es segura!Don't climb up on that chair. It isn't secure!
En esta economía, los trabajos seguros no abundan.In this economy, there aren't a lot of secure jobs.
4. (trustworthy)
a. reliable
Él no es una fuente de información segura.He is not a reliable source of information.
5. (self-assured)
a. confident
Ahora soy una persona más segura que lo que era de más joven.I'm a more confident person now than when I was younger.
An adverb is a word that describes a verb, an adjective, or other adverbs (e.g. to run quickly, very tired).
6. (without doubt)
a. for sure
Seguro que superaremos estas dificultades.We will overcome these troubles for sure.
b. surely
Miguel vendrá a la fiesta, de seguro.Miguel will surely come to the party.
A masculine noun is used with masculine articles and adjectives (e.g. el hombre guapo, el sol amarillo).
7. (indemnification in case of accidents)
a. insurance
Después del accidente me subieron la prima de seguro de coche.After the accident they raised my car insurance premium.
8. (device)
a. lock
Acabo de instalar el seguro en esta puerta.I've just installed a lock in this door.
b. safety (guns)
¿Tiene un buen seguro tu pistola?Does your gun have a good safety?
c. safety pin
Regionalism used in Mexico
(Mexico)
Se me rompió el zipper, así que usé un seguro para cerrar el vestido.The zipper broke, so I used a safety pin to close the dress.
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