Quick answer
"De qué" is a phrase which is often translated as "what", and "estar seguro" is an intransitive verb phrase which is often translated as "to be safe". Learn more about the difference between "de qué" and "estar seguro" below.
de qué(
deh
 
keh
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (interrogative)
a. what
Necesito saber de qué se trata.I need to know what it's about.
¿De qué estás hablando?What are you talking about?
b. which
Platicaron acerca de qué escuela iban a elegir para su hija.They talked about which school they would choose for their daughter.
c. from which
¿De qué país eres?Which country are you from?
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estar seguro(
ehs
-
tahr
 
seh
-
goo
-
roh
)
An intransitive verb phrase is a phrase that combines a verb with a preposition or other particle and does not require a direct object (e.g. Everybody please stand up.).
intransitive verb phrase
1. (to be out of danger)
a. to be safe
Construyeron refugios antiatómicos donde la población podía estar segura.They built nuclear shelters where the population could be safe.
2. (to be confident in an idea)
a. to be sure
Esta es la forma correcta de hacerlo. - ¿Estás segura?This is the right way to do it. - Are you sure?
3. (to be stable)
a. to be secure
¿Está seguro este andamio? ¿Puedo subir?Is this scaffold secure? Can I climb up?
4. (to be self-assured)
a. to be confident
Jim estaba muy seguro de sí mismo, pero yo no veía las cosas tan claras como él.Jim was very self-confident, but I didn't see things as clearly as he did.
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