Quick answer
"De qué" is a phrase which is often translated as "what", and "con que" is a preposition which is often translated as "as long as". Learn more about the difference between "de qué" and "con que" below.
de qué(
deh
 
keh
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (interrogative)
a. what
Necesito saber de qué se trata.I need to know what it's about.
¿De qué estás hablando?What are you talking about?
b. which
Platicaron acerca de qué escuela iban a elegir para su hija.They talked about which school they would choose for their daughter.
c. from which
¿De qué país eres?Which country are you from?
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con que(
kohn
 
keh
)
A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (introducing a condition)
a. as long as
Me contento con que arregles tu habitación.I am satisfied as long as you tidy up your room.
2. (introducing the use something is put to)
a. with which
La policía no ha encontrado todavía el arma con que dispararon a la víctima.The police haven't yet found the weapon with which the victim was shot.
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