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Quick answer
"De qué manera" is a phrase which is often translated as "in which way", and "en" is a preposition which is often translated as "in". Learn more about the difference between "de qué manera" and "en" below.
de qué manera(
deh
 
keh
 
mah
-
neh
-
rah
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (general)
a. in which way
¿De qué manera podemos ayudarte?In which way can we help you?
b. in what way
Fue una crítica constructiva. ¿De qué manera te ofendió lo que dije?It was constructive criticism. In what way did what I say offended you?
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en(
ehn
)
A preposition is a word that indicates the relationship between a noun and another word (e.g. He ran through the door.).
1. (indicating place)
a. in
Hay comida ya preparada en el supermercado.There's ready-made food in the supermarket.
b. on
Puedes poner los cubiertos en la mesa.You can put the silverware on the table.
2. (indicating time)
a. on
En 1969, aterrizamos en la luna.In 1969, we landed on the moon.
3. (indicating mode)
a. in
Si un oso te persigue, corre en zigzag.If a bear is chasing you, run in a zig-zag formation.
4. (transport)
a. by
No vinimos en avión, vinimos en tren.We didn't come by plane. We came by train.
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