vs 

QUICK ANSWER
"En" is a form of "en", a preposition which is often translated as "in". "De esta manera" is a phrase which is often translated as "in this way". Learn more about the difference between "de esta manera" and "en" below.
de esta manera(
deh
 
ehs
-
tah
 
mah
-
neh
-
rah
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. in this way
No debemos actuar de esta manera.We shouldn't act in this way.
b. this way
¿Cómo puedes tratar a Craig de esta manera?How can you treat Craig this way?
c. like this
Siento seguir molestándote de esta manera, pero necesito tu ayuda.I'm sorry to keep bothering you like this, but I need your help.
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en(
ehn
)
A preposition is a word that indicates the relationship between a noun and another word (e.g., He ran through the door.).
preposition
a. in
Hay comida ya preparada en el supermercado.There's ready-made food in the supermarket.
b. on
Puedes poner los cubiertos en la mesa.You can put the silverware on the table.
c. at
Los niños están en la escuela.The kids are at school.
a. in
En 1969 aterrizamos en la luna.In 1969, we landed on the moon.
a. in
Si un oso te persigue, corre en zigzag.If a bear is chasing you, run in a zig-zag formation.
a. by
No vinimos en avión; vinimos en tren.We didn't come by plane. We came by train.
a. about
¿En qué piensas?What are you thinking about?
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