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QUICK ANSWER
"Cómo me duele" is a form of "cómo me duele", a phrase which is often translated as "it hurts so much". "Ay" is a form of "ay", an interjection which is often translated as "ow". Learn more about the difference between "cómo me duele" and "ay" below.
cómo me duele(
koh
-
moh
meh
dweh
-
leh
)A phrase is a group of words commonly used together (e.g., once upon a time).
a. it hurts so much
Mamá, me caí y me hice daño en la rodilla. ¡Cómo me duele!Mom, I fell and hurt my knee. It hurts so much!
c. it aches so much
Tengo una úlcera de estómago. ¡Cómo me duele cuando como algo picante!I have a stomach ulcer. It aches so much when I eat spicy food!
d. aches so much
¡Cómo me duele la cabeza! Parece que me va a estallar.My head aches so much! It seems as if it were going to explode.
a. it hurts so much
Cómo me duele que mi hijo nunca me volviera a llamar.It hurts so much that my son never called me again.
ay(
ay
)An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g., Wow!).
b. jeez (colloquial)
A word or phrase that is commonly used in conversational speech (e.g., skinny, grandma).
¡Ay! Me asustaste.Jeez! You scared me.
A masculine noun is used with masculine articles and adjectives (e.g., el hombre guapo, el sol amarillo).