ruta principal

la ruta principal
A feminine noun is almost always used with feminine articles and adjectives (e.g., la mujer bonita, la luna llena).
feminine noun
a. main route
En caso de ventisca, se quita la nieve de las rutas principales primero y de las carreteras secundarias después.In case of a snowstorm, the snow is cleared from the main routes first, and then from the side roads.
b. main line
El sabotaje afectó a las rutas principales de la red de ferrocarriles del estado.The sabotage affected the main lines of the state's railroad network.
c. arterial
Las autopistas son las rutas principales de la red de carreteras interestatales.Freeways are the arterials of the interstate road network.
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