A feminine noun is almost always used with feminine articles and adjectives (e.g. la mujer bonita, la luna llena).
1. (mark)
a. small stain
Tienes una manchita en la camisa.You've got a small stain on your shirt.
2. (stigma)
a. small blot
Una manchita en tu reputación comercial puede hacerte mucho daño.A small blot on your business reputation can cause a lot of damage.
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