gran amigo

el gran amigo, la gran amiga
This means that the noun can be masculine or feminine, depending on the gender of the noun it refers to (e.g., el doctor, la doctora).
masculine or feminine noun
a. good friend
Una gran amiga mía siempre dice que para ella la amistad es más importante que el amor.A good friend of mine always says that friendship is more important to her than love.
b. great friend
Eres un gran amigo. Estás a mi lado siempre que te necesito.You're a great friend. You're there for me whenever I need you.
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