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See the entry forde qué hablas.
¿De qué hablas?
-What are you talking about?
See the entry for¿De qué hablas?

de qué hablas

de qué hablas(
deh
 
keh
 
ah
-
blahs
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
1.
A word or phrase used to refer to the second person informal “tú” by their conjugation or implied context (e.g., How are you?).
(informal)
(in statements; singular)
a. what you're talking about
Esta mañana no hiciste la cama. - No sé de qué hablas. ¡Claro que la hice!You didn't make your bed this morning. - I don't know what you're talking about. Of course I did!
2.
A word or phrase used to refer to the second person informal “tú” by their conjugation or implied context (e.g., How are you?).
(informal)
(in questions; singular)
a. what are you talking about
Lo que le dijiste a Ana fue insultante. - ¿De qué hablas si tú ni siquiera estabas allí?What you told Ana was insulting. - What are you talking about when you weren't even there?
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