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amigo del alma

el amigo del alma, la amiga del alma
This means that the noun can be masculine or feminine, depending on the gender of the noun it refers to (e.g., el doctor, la doctora).
masculine or feminine noun
a. best friend
Katie y Libby se hicieron amigas del alma en el campamento de verano.Katie and Libby became best friends at summer camp.
b. BFF
Natalie es mi amiga del alma, y va a ser una de mis damas de honor.Natalie is my BFF, and she's going to be one of my bridesmaids.
c. bosom buddy
Regionalism used in the United States
(United States)
Los dos primos han sido amigos del alma desde la infancia.The two cousins have been bosom buddies since childhood.
d. boon companion
A word or phrase restricted in usage to literature or established writing (e.g., sex, once upon a time).
(literary)
Regionalism used in the United Kingdom
(United Kingdom)
Era su amigo del alma que se había estado a su lado en las buenas y en las malas.He was his boon companion who had stuck with him through thick and thin.
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