what's up(
1. (colloquial) (used in questions) 
a. qué tal 
What's up? It's good to see you again.¿Qué tal? Me da gusto verte de nuevo.
b. qué pasa 
Hey, Michael! What's up with you?¡Oye, Michael! ¿Qué pasa contigo?
c. qué hay 
Rosita, what's up in town?Rosita, ¿qué hay en el pueblo?
d. qué onda (colloquial) (Latin America) 
Good morning, Fred! What's up?¡Buenos días, Fred! ¿Qué onda?
e. pasa algo 
What's up? You look a little sick.¿Pasa algo? Te ves un poco mal.
2. (used in statements) 
They bought a new house. That's what's up with them.Compraron una casa nueva. Eso es lo que pasa con ellos.
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