QUICK ANSWER
"Whose" is a pronoun which is often translated as "de quién", and "who's" is a contraction which is often translated as "quién es". Learn more about the difference between "whose" and "who's" below.
whose(
huz
)A pronoun is a word that stands in for a noun (e.g., she).
1. (possessive)
An adjective is a word that describes a noun (e.g., the big dog).
2. (possessive)
who's(
huz
)A contraction is a shortened form of a word or group of words made by omitting a sound or letter (e.g., don't).
a. quién es
Who's the man sitting next to you? - My cousin.¿Quién es el hombre sentado a tu lado? - Mi primo.
a. que está
The girl who's talking to Sarah is my new girlfriend.La chica que está hablando con Sarah es mi nueva novia.
a. quién ha
I've no idea who's been spreading these rumors.No tengo idea de quién ha hecho correr estos rumores.