Quick answer
"Who knows" is a phrase which is often translated as "quién sabe", and "how come" is an adverb which is often translated as "cómo es que". Learn more about the difference between "who knows" and "how come" below.
who knows
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (general)
a. quién sabe
Is this food for everybody? - Who knows? But I'm going to eat it.¿Esta comida es para todos? - ¿Quién sabe? Pero yo la voy a comer.
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how come
An adverb is a word that describes a verb, an adjective, or other adverbs (e.g. to run quickly, very tired).
1.
A word or phrase that is commonly used in conversational speech (e.g. skinny, grandma).
(colloquial)
(general)
a. cómo es que
How come you threw away your lunch?¿Cómo es que botaste tu almuerzo?
b. por qué
How come you quit your job?¿Por qué dejaste tu trabajo?
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