Quick answer
"What's up" is a phrase which is often translated as "qué tal", and "How are you?" is a phrase which is often translated as "¿Cómo estás?". Learn more about the difference between "what's up" and "How are you?" below.
what's up(
wuhts
 
uhp
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1.
A word or phrase that is commonly used in conversational speech (e.g. skinny, grandma).
(colloquial)
(used in questions)
a. qué tal
What's up? It's good to see you again.¿Qué tal? Me da gusto verte de nuevo.
b. qué pasa
Hey, Michael! What's up with you?¡Oye, Michael! ¿Qué pasa contigo?
c. qué hay
Rosita, what's up in town?Rosita, ¿qué hay en el pueblo?
d. qué onda
A word or phrase that is commonly used in conversational speech (e.g. skinny, grandma).
(colloquial)
Regionalism used in Latin America: all the countries in South America, Central America, and the Caribbean. Does not include Spain.
(Latin America)
Good morning, Fred! What's up?¡Buenos días, Fred! ¿Qué onda?
e. pasa algo
What's up? You look a little sick.¿Pasa algo? Te ves un poco mal.
2. (used in statements)
a. lo que pasa
They bought a new house. That's what's up with them.Compraron una casa nueva. Eso es lo que pasa con ellos.
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How are you?(
hau
 
ar
 
yu
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (used to address one person)
a. ¿Cómo estás?
A word of phrase used to refer to the second person informal “tú” by their conjugation or implied context (e.g. How are you?).
(informal)
(singular)
Hi, Sarah! How are you?¡Hola, Sarah! ¿Cómo estás?
b. ¿Cómo está?
A word or phrase used to refer to the second person formal “usted” by their conjugation or implied context (e.g. usted).
(formal)
(singular)
It's so nice to see you, Mr. Smith. How are you?¡Qué gusto verlo, Sr. Smith! ¿Cómo está?
2. (used to address multiple people)
a. ¿Cómo están? (plural)
Hey, guys! How are you?¡Hola, muchachos! ¿Cómo están?
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