Quick answer
"What a shame!" is an interjection which is often translated as "¡Qué pena!", and "oh" is an interjection which is often translated as "oh". Learn more about the difference between "What a shame!" and "oh" below.
What a shame!(
wuhd
 
uh
 
sheym
)
An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g. Wow!).
1. (general)
a. ¡Qué pena!
What a shame! Jessica didn't win first place.¡Qué pena! Jessica no ganó el primer lugar.
b. ¡Qué lástima!
It's on sale for today only, but I won't have the money to buy it until tomorrow. - What a shame!Está de oferta solo hoy, pero no tendré el dinero para comprarla hasta mañana. - ¡Qué lástima!
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oh(
o
)
An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g. Wow!).
1. (used to express surprise)
a. oh
Did you know there were going to be fireworks tonight? - Oh? No, I didn't.¿Sabías que iba a haber fuegos artificiales esta noche? - ¡Oh! No, no lo sabía.
b. vaya
Oh! What a pleasant surprise to see you here!¡Vaya! ¡Qué sorpresa tan agradable verte aquí!
c. ah
Oh! I get it now. The TV won't turn on because it's not plugged in!¡Ah! Ya entendí. ¡La tele no se enciende porque no está enchufada!
2. (used to express pain)
a. ay
Oh! That's hot.¡Ay! Eso está caliente.
3. (used to call attention)
a. eh
Oh, sir, you're stepping on my shoe!¡Eh, señor! Me está pisando.
4. (used to express disbelief)
a. en serio
Oh? You're going to be the master of ceremonies?¿En serio? ¿Vas a ser el maestro de ceremonias?
b. no me digas
Oh, you have got to be kidding. Steve's going out with Melanie again?¡No me digas! Debe ser una broma. ¿Steve está saliendo de nuevo con Melanie?
c. de veras
Oh? You won the gold medal?¿De veras? ¿Ganaste la medalla de oro?
5. (used to express dismay)
a. ay
Oh! Shut up! That is disgusting!¡Ay! ¡Cállate! ¡Eso es asqueroso!
6. (used to elicit further information)
a. ah, sí
I'm leaving early today. - Oh?Hoy salgo temprano. - ¿Ah, sí?
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