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QUICK ANSWER
"¡Uy!" is an interjection which is often translated as "Oh!", and "lo siento" is a phrase which is often translated as "I'm sorry". Learn more about the difference between "¡Uy!" and "lo siento" below.
¡Uy!(
ooee
)An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g., Wow!).
lo siento(
loh
syehn
-
toh
)A phrase is a group of words commonly used together (e.g., once upon a time).
a. I'm sorry
Me enteré del fallecimiento de tu padre. Lo siento.I heard about the death of your father. I'm sorry.