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"Serio" is a form of "serio", an adjective which is often translated as "serious". "Responsable" is an adjective which is often translated as "responsible". Learn more about the difference between "serio" and "responsable" below.
serio()
An adjective is a word that describes a noun (e.g., the big dog).
2. (grave)
a. serious
El juez lo condenó a cadena perpetua por cometer un delito serio.The judge gave him a life sentence because he committed a serious crime.
a. reliable
Estoy buscando a una niñera seria, cariñosa y paciente para cuidar a mis hijos.I'm looking for a reliable, loving, and patient nanny to take care of my children.
responsable()
An adjective is a word that describes a noun (e.g., the big dog).
a. responsible
Sergio fue responsable y guardó todos sus juguetes.Sergio was responsible and put away all his toys.
b. in charge
¿Puedo hablar con la persona responsable de la tienda?Can I speak with the person in charge of the store?
c. liable
Los inquilinos son responsables de cualquier daño al apartamento.Tenants are liable for any damages to the apartment.
2. (reliable)
a. responsible
George es muy responsable; siempre hace la tarea.George is very responsible; he always does his homework.
3. (guilty)
a. responsible
Buscamos a la persona responable del asesinato.We seek the person responsible for the murder.
This means that the noun can be masculine or feminine, depending on the gender of the noun it refers to (e.g., el doctor, la doctora).
4. (manager)
a. person in charge
Ya son las 10 am. Digo, ¿a qué hora llega el responsable?It's 10 am already. I mean, when does the person in charge get here?
a. guilty party
El responsable será encontrado, llevado a juicio y encarcelado.The guilty party will be found, tried, and imprisoned.
b. culprit
¿Quién es el responsable de este terrible crimen?Who is the culprit of this terrible crime?