vs
QUICK ANSWER
"Que" is an abbreviation which is often translated as "Que", and "to be interested in" is a transitive verb phrase which is often translated as "interesar". Learn more about the difference between "Que" and "to be interested in" below.
Que(
kweh
-
behk
)An abbreviation is the shortened form of a word or group of words (e.g., "UFO" = "unidentified flying object"; "p." = "page").
to be interested in(   
tuh
bi
ihn
-
trihs
-
dihd
ihn
)A transitive verb phrase is a phrase that combines a verb with a preposition or other particle and requires a direct object (e.g., take out the trash.).
1. (general)
a. interesar 
I am interested in helping students to achieve the most they possibly can.Me interesa ayudar a los estudiantes a lograr todo lo que puedan.
b. estar interesado en 
Camille is interested in a wide range of topics.Camille está interesada en una amplia gama de temas.
c. tener interés en 
I am interested in learning more about her.Tengo interés en aprender más sobre ella.
d. tener un interés en 
We are interested in understanding his motivations.Tenemos un interés en entender sus motivaciones.