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"Mrs." is an abbreviation which is often translated as "Sra.", and "madame" is a noun which is often translated as "señora". Learn more about the difference between "Mrs." and "madame" below.
Mrs.()
An abbreviation is the shortened form of a word or group of words (e.g., "UFO" = "unidentified flying object"; "p." = "page").
madame()
A noun is a word referring to a person, animal, place, thing, feeling, or idea (e.g., man, dog, house).