vs
QUICK ANSWER
"Madame" is a noun which is often translated as "señora", and "Mrs." is an abbreviation which is often translated as "Sra.". Learn more about the difference between "madame" and "Mrs." below.
madame()
A noun is a word referring to a person, animal, place, thing, feeling, or idea (e.g., man, dog, house).
Mrs.()
An abbreviation is the shortened form of a word or group of words (e.g., "UFO" = "unidentified flying object"; "p." = "page").