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"It's" is a form of "it's", a contraction which is often translated as "es". "In fact" is a phrase which is often translated as "de hecho". Learn more about the difference between "it's" and "in fact" below.
it's(
ihts
)A contraction is a shortened form of a word or group of words made by omitting a sound or letter (e.g., don't).
in fact(
ihn
fahkt
)A phrase is a group of words commonly used together (e.g., once upon a time).
1. (actually)
a. de hecho
That restaurant is closed. In fact, the other five locations have closed also. Ese restaurante ha cerrado. De hecho, los otro cinco locales han cerrado también.
c. en efecto
He said he couldn't make it on time and, in fact, he was absent.Dijo que no llegaría a tiempo y, en efecto, estuvo ausente.