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QUICK ANSWER
"Hola" is a form of "hola", an interjection which is often translated as "hello". "Cómo están ustedes" is a form of "cómo están ustedes", a phrase which is often translated as "how you are". Learn more about the difference between "hola" and "cómo están ustedes" below.
hola
An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g., Wow!).
1. (general)
b. hi (colloquial)
A word or phrase that is commonly used in conversational speech (e.g., skinny, grandma).
¡Hola! ¿Qué hay de nuevo?Hi! What's new?
cómo están ustedes(
koh
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moh
ehs
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tahn
oos
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tehd
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ehs
)A phrase is a group of words commonly used together (e.g., once upon a time).
a. how you are
Bueno, basta de hablar de mí, ahora díganme cómo están ustedes.Well, enough about me, now tell me how you are.
a. how are you
¿Cómo están ustedes dos? ¿Les gusta vivir en Londres?How are you two? Are you enjoying your life in London?