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QUICK ANSWER
"What?" is a form of "What?", an interjection which is often translated as "¿Qué?". "Excuse me" is a phrase which is often translated as "perdón". Learn more about the difference between "excuse me" and "What?" below.
excuse me(
ehk
-
skyuz
mi
)A phrase is a group of words commonly used together (e.g., once upon a time).
What?(
wuht
)An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g., Wow!).
a. ¿Qué?
I bought a new car. - What? We can't afford that!Compré un coche nuevo. ¿Qué? ¡No podemos pagar eso!
