Quick answer
"De qué" is a phrase which is often translated as "what", and "que" is a conjunction which is often translated as "that". Learn more about the difference between "de qué" and "que" below.
de qué(
deh
 
keh
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (interrogative)
a. what
Necesito saber de qué se trata.I need to know what it's about.
¿De qué estás hablando?What are you talking about?
b. which
Platicaron acerca de qué escuela iban a elegir para su hija.They talked about which school they would choose for their daughter.
c. from which
¿De qué país eres?Which country are you from?
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que(
keh
)
A conjunction is a word that connects words, phrases, clauses, or sentences (e.g. The cat and the dog slept.).
1. (used to introduce a subordinate clause)
a. that
Tenga en cuenta que algunas de estas características son diferentes.Note that some of these characteristics are different.
A pronoun is a word that stands in for a noun (e.g. she).
2. (used to define the subject)
a. who (person)
El hombre que le salvó la vida a mi bebé está aquí.The man who saved my baby's life is here.
b. which (thing)
El libro que más ha influido en mí es este.The book which has had the greatest influence on me is this one.
c. that (thing)
El pastel que me encanta es el de chocolate.The cake that I love is chocolate cake.
3. (used to define the object)
a. who (person)
Vi a la mujer que trabaja en el spa.I saw the woman who works in the spa.
b. which (thing)
¡Enséñame el vestido que llevaste en la fiesta!Show me the dress which you wore to the party!
c. that (thing)
Ese es el teléfono que yo quiero.That's the phone that I want.
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