Quick answer
"De lo que" is a phrase which is often translated as "of what", and "por la que" is a phrase which is often translated as "by which". Learn more about the difference between "de lo que" and "por la que" below.
de lo que(
deh
 
loh
 
keh
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (general)
a. of what
Gran parte de lo que dice el libro es información que está disponible en Internet.Much of what the book says is information you can find on the Internet.
b. which
Estudié italiano, de lo que no me arrepiento.I studied Italian, which I don't regret.
c. than
Esto es más de lo que yo esperaba.This is more than I expected.
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por la que
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (by means of which)
a. by which
La ruta por la que se administrará el medicamento depende de la droga en sí.The route by which the medication will be administered is dictated by the drug itself.
2. (out of which)
a. through which
Había sangre en la ventana por la que escaparon los ladrones.There was blood on the window through which the burglars escaped.
3. (because of which)
a. why
Se desconoce la razón por la que no vino.The reason why he didn't come is unknown.
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