Quick answer
"De lo que" is a phrase which is often translated as "of what", and "de qué" is a phrase which is often translated as "what". Learn more about the difference between "de lo que" and "de qué" below.
de lo que(
deh
 
loh
 
keh
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (general)
a. of what
Gran parte de lo que dice el libro es información que está disponible en Internet.Much of what the book says is information you can find on the Internet.
b. which
Estudié italiano, de lo que no me arrepiento.I studied Italian, which I don't regret.
c. than
Esto es más de lo que yo esperaba.This is more than I expected.
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de qué(
deh
 
keh
)
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (interrogative)
a. what
Necesito saber de qué se trata.I need to know what it's about.
¿De qué estás hablando?What are you talking about?
b. which
Platicaron acerca de qué escuela iban a elegir para su hija.They talked about which school they would choose for their daughter.
c. from which
¿De qué país eres?Which country are you from?
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