Quick answer
"De este modo" is an adverb which is often translated as "this way", and "en este sentido" is a phrase which is often translated as "in this regard". Learn more about the difference between "de este modo" and "en este sentido" below.
de este modo(
deh
 
ehs
-
teh
 
moh
-
doh
)
An adverb is a word that describes a verb, an adjective, or other adverbs (e.g. to run quickly, very tired).
1. (in such way)
a. this way
¿Se debe moler las papas de este modo? Nunca lo he hecho.Am I supposed to mash the potatoes this way? I've never done it before.
2. (therefore)
a. thus
De este modo, podemos concluir que los resultados sí tienen relevancia estadística.Thus, we can conclude that the results are statistically significant.
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en este sentido
A phrase is a group of words commonly used together (e.g once upon a time).
phrase
1. (in connection with this)
a. in this regard
Es urgente tomar medidas en este sentido.Urgent action is needed in this regard.
b. in this respect
El trabajo que estamos realizando en este sentido es muy importante.The work we are doing in this respect is very important.
2. (in this meaning)
a. in this sense
En este sentido, la palabra tiene connotaciones negativas.In this sense, the word has negative connotations.
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