vs 

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"Cuáles" is a form of "cuál", a pronoun which is often translated as "which". "De qué" is a phrase which is often translated as "what". Learn more about the difference between "cuáles" and "de qué" below.
cuál(
kwahl
)
A pronoun is a word that stands in for a noun (e.g., she).
pronoun
a. which (among a group of options)
¿Cuál de estas camisas me queda mejor?Which of these shirts suits me best?
b. which one (among a group of options)
No sé cuál quiere.I don't know which one she wants.
¿Cuál es mejor?Which one is better?
c. what
¿Cuál es la diferencia?What's the difference?
An adjective is a word that describes a noun (e.g., the big dog).
adjective
a. which (among a group of options)
¿Cuál color iría mejor en el salón?Which color would look best in the living room?
b. what
¿Cuál género de música prefieres?What genre of music do you prefer?
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de qué(
deh
 
keh
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. what
Necesito saber de qué se trata.I need to know what it's about.
¿De qué estás hablando?What are you talking about?
b. which
Platicaron acerca de qué escuela iban a elegir para su hija.They talked about which school they would choose for their daughter.
c. from which
¿De qué país eres?Which country are you from?
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