vs 

QUICK ANSWER
"Hola, guapo" is a form of "hola, guapo", a phrase which is often translated as "hi, handsome". "¿Cómo estás?" is a phrase which is often translated as "How are you?". Learn more about the difference between "¿Cómo estás?" and "hola, guapo" below.
¿Cómo estás?(
koh
-
moh
 
ehs
-
tahs
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
1.
A word or phrase used to refer to the second person informal “tú” by their conjugation or implied context (e.g., How are you?).
(informal)
(salutation; singular)
a. How are you?
¡Hola, amiga! ¿Cómo estás?Hey, friend! How are you?
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hola, guapo(
oh
-
lah
 
gwah
-
poh
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. hi, handsome
Hola, guapo. Soy Sofía. ¿Te molesta si me siento aquí? - No, para nada.Hi, handsome. I'm Sofia. Do you mind if I sit here? - No, of course not.
b. hello, handsome
Hola, guapo. ¿Te han dicho que tienes una sonrisa muy bonita?Hello, handsome. Has anyone ever told you that you have a beautiful smile?
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