vs 

QUICK ANSWER
"Can you help me?" is a phrase which is often translated as "¿Me puedes ayudar?", and "excuse me" is a phrase which is often translated as "perdón". Learn more about the difference between "Can you help me?" and "excuse me" below.
Can you help me?(
kahn
 
yu
 
hehlp
 
mi
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. ¿Me puedes ayudar?
A word or phrase used to refer to the second person informal “tú” by their conjugation or implied context (e.g., How are you?).
(informal)
(singular)
I can't carry this by myself. Can you help me?No puedo cargar esto yo solo. ¿Me puedes ayudar?
b. ¿Me ayudas?
A word or phrase used to refer to the second person informal “tú” by their conjugation or implied context (e.g., How are you?).
(informal)
(singular)
I can't work out the answer to this sum. Can you help me?No sé hacer esta cuenta. ¿Me ayudas?
c. ¿Me puede ayudar?
A word or phrase used to refer to the second person formal “usted” by their conjugation or implied context (e.g., usted).
(formal)
(singular)
Excuse me, sir, can you help me, please?Disculpe, señor, ¿me puede ayudar, por favor?
d. ¿Me ayuda?
A word or phrase used to refer to the second person formal “usted” by their conjugation or implied context (e.g., usted).
(formal)
(singular)
Can you help me with this spreadsheet, please?¿Me ayuda con esta hoja de cálculo, por favor?
a. ¿Me ayudan? (plural)
Can you help me with these boxes if you're not busy?¿Me ayudan con estas cajas si no están ocupados?
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excuse me(
ehk
-
skyuz
 
mi
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. perdón
Excuse me. Could I have a menu, please?Perdón, ¿me puede traer un menú, por favor?
b. disculpe
Excuse me. Is this the right train for New York?Disculpe, ¿es este el tren para ir a Nueva York?
a. perdone
Excuse me; I didn't hear what you said.Perdone, no oí lo que dijo.
b. cómo (less formal)
Have you seen Anna? - Excuse me?¿Has visto a Anna? - ¿Cómo?
a. perdone
Excuse me! I thought this seat was free.¡Perdone! Pensé que este asiento estaba libre.
b. perdón
I didn't realize you were in a meeting. Excuse me.No me di cuenta de que estabas en una reunión. Perdón.
a. permiso
He didn't even say "excuse me"; he just barged past.Ni siquiera dijo "permiso", pasó a empujones.
a. permítame
Please excuse me a minute. I need to check something.Permítame un momento, por favor. Tengo que comprobar algo.
a. un momento
Excuse me! I was first in line.¡Un momento! Yo estaba primero.
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