vs 

QUICK ANSWER
"Cómo se llama" is a form of "cómo se llama", a phrase which is often translated as "what his name is". "Quién es" is a form of "quién es", a phrase which is often translated as "who is". Learn more about the difference between "cómo se llama" and "quién es" below.
cómo se llama(
koh
-
moh
 
seh
 
yah
-
mah
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. what his name is
No sé cómo se llama, solo lo conozco de vista.I don't know what his name is. I only know him by sight.
b. what her name is
No me acuerdo de cómo se llama. ¿Rosa quizá?I can't recall what her name is. Rosa maybe?
c.
This refers to an idiomatic word or phrase for which there is no word-for-word translation.
no direct translation
Me pregunto cómo se llama el primo de María. Es muy guapo.I wonder what Maria's cousin's name is. He's very handsome.
Si sabes cómo se llama esa señora, podemos buscar su número de teléfono en la guía.If you know that lady's name, we can look her phone number up in the directory.
a. what it's called
Si vamos a la tienda de electrodomésticos a comprar ese aparato, necesitamos saber cómo se llama.If we're going to the appliance store to buy that device, we need to know what it's called.
b.
This refers to an idiomatic word or phrase for which there is no word-for-word translation.
no direct translation
Le preguntaré al informático cómo se llama ese programa.I'll ask the computer specialist what that program is called.
Cuando sepa cómo se llama ese tipo de lana, te lo digo.When I find out what that kind of wool is called, I'll let you know.
3.
A word or phrase used to refer to the second person formal “usted” by their conjugation or implied context (e.g., usted).
(formal)
(in statements; second person singular)
a. what your name is
Lo siento, sé que nos presentaron, pero no recuerdo cómo se llama. - Me llamo Ana.I'm sorry. I know we were introduced, but I can't remember what your name is. - My name is Ana.
a. what's his name
Seguro que conoces a su novio, fue a la escuela contigo. - ¿Y cómo se llama?I'm sure you know her boyfriend. He went to school with you. - And what's his name?
b. what's her name
No se llama Matilde - ¿Cómo se llama entonces?Her name isn't Matilde. - What's her name then?
c.
This refers to an idiomatic word or phrase for which there is no word-for-word translation.
no direct translation
¿Cómo se llama la profesora de español? - Lola.What's the Spanish teacher's name? - Lola.
¿Cómo se llama tu padre? ¿Se llama igual que tú?What's your father's name? Is it the same as yours?
a. what's it called
Si no se llama así, ¿cómo se llama?If it's not called that, what's it called?
b.
This refers to an idiomatic word or phrase for which there is no word-for-word translation.
no direct translation
Luisa, ¿cómo se llama ese concurso que tú ves en la tele?Luisa, what's that quiz you watch on TV called?
¿Cómo se llama esa planta de ahí? - Ficus.What's that plant over there called? - Rubber plant.
6.
A word or phrase used to refer to the second person formal “usted” by their conjugation or implied context (e.g., usted).
(formal)
(in questions; second person singular)
a. what's your name
¿Cómo se llama si no es Victoria? - Me llamo Virginia.What's your name if it's not Victoria? - My name is Virginia.
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quién es(
kyehn
 
ehs
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. who is
Pronto sabremos quién es el ganador del concurso.We will soon know who the winner of the contest is.
b. who's
Yo sé quién es detrás de esa máscara.I know who's behind that mask.
c. who he is (masculine)
Juan sufrió un golpe a la cabeza y ya no sabe quién es.John suffered a blow to the head and no longer knows who he is.
d. who she is (feminine)
¿Ves a la señorita del vestido rojo? Quiero saber quién es.Do you see the young woman in the red dress? I want to know who she is.
a. Who is it?
Alguien está tocando. - ¿Quién es?Someone is knocking. - Who is it?
b. who's
¿Quién es el encargado aquí?Who's in charge here?
c. who is
¿Quién es el encargado de sacar hoy la basura?Who is going to take out the trash today?
d. who is he (masculine)
¡No es mi novio! - Entonces, ¿quién es?He isn't my boyfriend. - So, who is he then?
e. who is she (feminine)
¿Ves a esa muchacha que nos está mirando? - Sí, ¿quién es?Do you see that girl watching us? - Yes, who is she?
3.
A word or phrase used to refer to the second person formal “usted” by their conjugation or implied context (e.g., usted).
(formal)
(second person singular; in questions)
a. who are you
¿Quién es usted para decidir eso?Who are you to take that decision?
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